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Multiple Sclerosis/Demyelinating Disease
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Your search returned 68 results
from the time period: last 30 days.
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Scientific reports 
Abstract: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS. There is currently no single definitive test for MS. Circulating exosomes represent promising candidate biomarkers for a host of human diseases. Exosomes contain RNA, DNA, and proteins, can cross the blood-brain barrier, and are secreted from almost all cell types including cells of ...
Immune System Diseases (2)
Multiple Sclerosis (10), Demyelinating Diseases (1), more mentions
Brain : a journal of neurology 
DescriptorName: Multiple Sclerosis... Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis; however, its underlying pathophysiological mechanisms, including its link to inflammatory demyelination and temporal occurrence in the disease course are still unknown ... integrity in the cortex and white matter in early stage multiple sclerosis, their distribution in lesional and normal-appearing tissue, and their ...
Immune System Diseases (10)
Multiple Sclerosis (10), Demyelination (2), Atrophy (1), more mentions
Neurology 
... disease activity, disability, and disease-modifying therapies (DMTs) on serum neurofilament light (NFL) and the correlation between NFL concentrations in serum and CSF in multiple sclerosis (MS) AbstractText: NFL concentrations were measured in paired serum and CSF samples (n = 521) from 373 participants: 286 had MS, 45 had other neurologic ...
Immune System Diseases (2)
Multiple Sclerosis (9), more mentions
Neurology 
... To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions ... CIS topographies AbstractText: Our results comply with the Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) consensus recommendation of combining cortical and juxtacortical lesions into a single ...
Immune System Diseases (3)
Multiple Sclerosis (3), Optic Neuritis (2), more mentions
Neurology
AbstractText: To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS AbstractText: All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls ...
Neurological and Central Nervous System Diseases (12), Immune System Diseases (2)
Multiple Sclerosis (13), Epilepsy (12), more mentions
Neurology
AbstractText: To evaluate the association between comorbidity and relapse rate in individuals with multiple sclerosis (MS) AbstractText: We recruited individuals with prevalent relapsing-onset MS from 4 Canadian MS Clinics to participate in a 2-year prospective multicenter cohort study involving cross-sectional assessment of comorbidities and relapses. Comorbidities were recorded using questionnaires, and relapses were captured from medical records ...
Pain Management (3), Immune System Diseases (2), Neuroscience (1)
Multiple Sclerosis (7), Migraine Disorders (3), Hyperlipidemias (3), more mentions
Brain : a journal of neurology
DescriptorName: Multiple Sclerosis... initiation of effective therapy is crucial for preventing disability in multiple sclerosis; however, treatment response varies greatly among patients... response using demographic, clinical and paraclinical predictors in patients with multiple sclerosis; and (ii) to evaluate accuracy, and internal and external validity ... validity was evaluated in a geographically distinct cohort, the Swedish Multiple Sclerosis Registry.
Immune System Diseases (6)
Multiple Sclerosis (6), more mentions
Brain : a journal of neurology
DescriptorName: Multiple Sclerosis... of multiple disease-modifying medications with regulatory approval to treat multiple sclerosis illustrates the substantial progress made in therapy of the disease ... neuroprotection, or repair of the damaged central nervous system in multiple sclerosis... summarize here the status of cell-based therapies to treat multiple sclerosis and make consensus recommendations for future research and clinical trials ...
Stem Cell Research (9), Immune System Diseases (6)
Multiple Sclerosis (6), more mentions
Brain : a journal of neurology 
DescriptorName: Multiple Sclerosis, Chronic Progressive. DescriptorName: Multiple Sclerosis, Relapsing-Remitting... is an important tool in the diagnosis and monitoring of multiple sclerosis patients... from microglial activation, and measures of subsequent disease progression in multiple sclerosis patients. Twenty-one patients with multiple sclerosis (seven with secondary progressive disease and 14 with a relapsing ...
Immune System Diseases (7)
Multiple Sclerosis (7), Atrophy (4), more mentions
Brain : a journal of neurology 
DescriptorName: Multiple Sclerosis, Chronic Progressive... Abstract: Prognostic markers of primary progressive multiple sclerosis evolution are needed... damage in predicting long-term clinical worsening of primary progressive multiple sclerosis compared to simple clinical assessment... of clinical and imaging measures allows identification of primary progressive multiple sclerosis patients at risk of long-term disease progression 4 years ...
Immune System Diseases (6)
Primary Progressive Multiple Sclerosis (5), Atrophy (2), Multiple Sclerosis (1), more mentions
Frontiers in immunology 
Abstract: Pathogenesis of autoimmune disorders, including multiple sclerosis (MS), has been linked to an alteration of the resident microbial commensal community and of the interplay between the microbiota and the immune system... Keyword: multiple sclerosis.
Immune System Diseases (4)
Multiple Sclerosis (6), more mentions
Multiple sclerosis (Houndmills, Basingstoke, England) 
AbstractText: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage ... VO2max, sit-to-stand test, Six-Minute Walk Test (6MWT), Multiple Sclerosis Walking Scale-12 (MSWS-12)) and cognitive function (Rao's Brief ... Scale for Motor and Cognitive Function (FSMC)), quality of life (Multiple Sclerosis Impact Scale-29 (MSIS-29)), and imaging.
Immune System Diseases (5)
Multiple Sclerosis (5), more mentions
Multiple sclerosis (Houndmills, Basingstoke, England) 
Abstract: Exercise benefits multiple sclerosis (MS) patients, but exercise-induced overheating is a deterrent for many... Aspirin may represent an effective pretreatment for exercise in MS Keyword: Multiple sclerosis. Keyword: aspirin. Keyword: body temperature. Keyword: exercise. Keyword: fatigue.
Immune System Diseases (3)
Multiple Sclerosis (5), more mentions
International journal of MS care 
... is a well-recognized cause of facial pain in the general population, and multiple sclerosis (MS) accounts for some of these cases... AbstractText: In 2009, we surveyed participants in the North America Research Committee on Multiple Sclerosis Registry regarding TN, including date of onset and pharmacologic and nonpharmacologic treatments used ...
Immune System Diseases (3)
Multiple Sclerosis (13), Trigeminal Neuralgia (2), Facial Pain (1), more mentions
PLoS computational biology 
DescriptorName: Magnetic Resonance Imaging. DescriptorName: Multiple Sclerosis... Abstract: Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS. However, it is not well understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous disease. We established a hypothesis whereby the variability in the course of MS ...
Immune System Diseases (5)
Multiple Sclerosis (13), Autoimmune Diseases (1), more mentions
JAMA neurology 
Increasing Evidence for an Association Between Amyotrophic Lateral Sclerosis and Psychiatric Disorders..
Neurological and Central Nervous System Diseases (2)
Amyotrophic Lateral Sclerosis (2), more mentions
Scientific reports 
Abstract: Cigarette smoking is an established environmental risk factor for Multiple Sclerosis (MS), a chronic inflammatory and neurodegenerative disease, although a mechanistic basis remains largely unknown. We aimed at investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers and never smokers in two Swedish cohorts, differing for known ...
Immune System Diseases (2), Smoking Cessation (1)
Multiple Sclerosis (8), Neurodegenerative Diseases (1), more mentions
Neurology
Pearls & Oy-sters: CNS lymphoma in a patient with relapsing-remitting multiple sclerosis treated with interferon..
Immune System Diseases (2)
Relapsing-Remitting Multiple Sclerosis (2), Lymphoma (2), more mentions
JAMA neurology
AbstractText: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition primarily involving the motor system. There is increasing epidemiologic evidence of an association between ALS and a wider spectrum of neurodegenerative and neuropsychiatric disorders among family members, including schizophrenia and psychotic illness and suicidal behavior AbstractText: To examine the frequency and range of neuropsychiatric conditions that occur within individual first ...
Neurological and Central Nervous System Diseases (15), Neuroscience (7)
Amyotrophic Lateral Sclerosis (15), Schizophrenia (4), Autistic Disorder (3), more mentions
Brain : a journal of neurology
Cerebral X-linked adrenoleukodystrophy is a devastating neurodegenerative disorder caused by mutations in the ABCD1 gene, which lead to a rapidly progressive cerebral inflammatory demyelination in up to 60% of affected males. Selective brain endothelial dysfunction and increased permeability of the blood-brain barrier suggest that white matter microvascular dysfunction contributes to the conversion to cerebral disease. Applying a vascular model to conventional dynamic susceptibility contrast magnetic resonance perfusion imaging, we demonstrate that lack of ABCD1 function causes increased capillary flow heterogeneity in asymptomatic hemizygotes predominantly in the white matter regions and developmental stages with the highest probability for conversion to cerebral disease. In subjects with ongoing inflammatory demyelination we observed a sequence of increased capillary flow heterogeneity followed by blood-brain barrier permeability changes in the perilesional white matter, which predicts lesion progression. These white matter microvascular alterations normalize within 1 year after treatment with haematopoietic stem cell transplantation. For the first time in vivo, our studies unveil a model to assess how ABCD1 alters white matter microvascular function and explores its potential as an earlier biomarker for monitoring disease progression and response to treatment.
Stem Cell Research (1)
Demyelination (3), Adrenoleukodystrophy (3), Neurodegenerative Diseases (1), more mentions
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