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Alzheimer Disease
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Alzheimer Disease (AD) is the most common neurodegenerative disorder in older individuals sixty years and older, typically characterized by memory problems and inability to independently perform activities of daily living. Common clinical presentations involve different degrees of memory impairment. Episodic memory for newly acquired information and declarative memory for facts and events are initially affected while memory of remote, procedural memory and motor learning are spared during early stages. With progression of the disease, language, visiospatial skills, abstract reasoning, and executive function deteriorate. Some individuals will also develop apraxia, alexia, and delusion. From the Washington Manual of Medical Therapeutics, 35e.

Your search returned 49 results
from the time period: last 30 days.
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Neurology
... vMRI) scans, could be used to identify variant subtypes of Alzheimer disease (AD) and to prospectively predict the rate of clinical decline AbstractText: Amyloid-positive participants with AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) 1 and ADNI2 with baseline MRI ... faster subsequent clinical decline than participants with LPMRI on the Alzheimer's Disease Assessment Scale, 13-Item Subscale (ADAS-Cog13), Mini-Mental ...
Neuroscience (4)
Alzheimer Disease (4), Atrophy (2), Dementia (1), more mentions
Neurology
Abstract: Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025... This proceedings article summarizes the 2016 Alzheimer's Disease-Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia ...
Neuroscience (8)
Alzheimer Disease (5), Dementia (4), Lewy Body Disease (1), more mentions
Neurology
... To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is ... PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were asymptomatic but at 50% risk of carrying ...
Neuroscience (1)
Atrophy (3), Alzheimer Disease (3), Dementia (1), more mentions
Annals of neurology
AbstractText: A reduction in glucose metabolism in the posterior cingulate cortex (PCC) predicts conversion to Alzheimer's disease (AD) and tracks disease progression, signifying its importance in AD... genome-wide association study (GWAS) of decline in PCC [(18) F] FDG PET measured in Alzheimer's Disease Neuroimaging Initiative (ADNI) participants (n=606.
Neuroscience (3)
Alzheimer Disease (3), Dementia (1), Neurodegenerative Diseases (1), more mentions
JAMA neurology
AbstractText: The prevalence of pathologic conditions of the brain associated with Alzheimer disease increases strongly with age. Little is known about the distribution and clinical significance of preclinical biomarker staging in the oldest old, when most individuals without dementia are likely to have positive biomarkers AbstractText: To compare the patterns of long-term cognitive decline in multiple domains by preclinical ...
Neuroscience (6)
Dementia (5), Atrophy (2), Alzheimer Disease (2), more mentions
Alzheimer's research & therapy 
However, this would require an updated understanding of Alzheimer's disease, namely the important distinction between Alzheimer's disease and Alzheimer's dementia AbstractText: Since treatments are likely to be most effective ... recent and anticipated developments in the understanding and treatment of Alzheimer's disease presents a great opportunity to innovate and adapt our ...
Neuroscience (9), Neurological and Central Nervous System Diseases (1)
Alzheimer Disease (8), Dementia (3), Neurodegenerative Diseases (1), more mentions
International journal of geriatric psychiatry 
... associated with new benzodiazepine and related drug (BZDR) use in a nationwide cohort of persons with Alzheimer disease (AD) AbstractText: The register-based MEDALZ cohort, including all community-dwelling Finns diagnosed with AD ... stating that nonpharmacological approaches should be the first-line option for symptomatic treatment of AD Keyword: Alzheimer disease.
Cardiovascular Diseases (1)
Alzheimer Disease (3), Substance Abuse (1), more mentions
Stem cell reports 
Abstract: Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course... Keyword: Alzheimer's disease. Keyword: Tau. Keyword: amyloid. Keyword: differential susceptibility. Keyword: disease modeling. Keyword: familial AD. Keyword: iPSCs. Keyword: neural stem cells. Keyword: selective vulnerability.
Neuroscience (3)
Alzheimer Disease (3), more mentions
Journal of the American Geriatrics Society 
... To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD) AbstractText: Systematic review and Bayesian network metaanalysis (NMA) AbstractText ... NMA found that donepezil (Alzheimer's Disease Assessment Scale-cognitive: MD = -3.29, 95% CrI = -4.57 to -1.99 ... effects than those treated with these drugs in clinical practice Keyword: Alzheimer's disease.
Neuroscience (7)
Alzheimer Disease (4), Bradycardia (1), Diarrhea (1), more mentions
Alzheimer's & dementia (New York, N. Y.) 
Abstract: Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early ... With this in mind, the Alzheimer's Association convened a Research Roundtable in May 2016, bringing together experts from academia, industry, and regulatory agencies ... Keyword: Alzheimer's disease.
Neuroscience (6), Neurological and Central Nervous System Diseases (1)
Alzheimer Disease (4), Depressive Disorder (2), Psychotic Disorders (1), more mentions
Alzheimer's & dementia (New York, N. Y.) 
AbstractText: The rate of clinical misdiagnosis of Alzheimer's disease (AD) and how psychosis impacts that clinical judgment is unclear AbstractText: Using data from National Alzheimer's Coordinating Center, we compared the clinical and neuropathologic diagnosis in patients with ... AD when vascular pathology is the underlying neuropathologic cause of dementia Keyword: Alzheimer's disease.
Neuroscience (5), Neurological and Central Nervous System Diseases (1)
Psychotic Disorders (6), Alzheimer Disease (4), Dementia (2), more mentions
The Lancet. Neurology 
AbstractText: Nutrition is an important modifiable risk factor in Alzheimer's disease... trials of the multinutrient Fortasyn Connect showed benefits in mild Alzheimer's disease dementia... of Fortasyn Connect on cognition and related measures in prodromal Alzheimer's disease... The trial enrolled individuals with prodromal Alzheimer's disease, defined according to the International Working Group (IWG)-1 ...
Neuroscience (10)
Alzheimer Disease (6), Dementia (2), Atrophy (1), more mentions
JAMA psychiatry 
AbstractText: The extent of dorsolateral prefrontal cortex (DLPFC) plasticity in Alzheimer disease (AD) and its association with working memory are not known AbstractText: To determine whether participants with AD had impaired DLPFC plasticity compared with healthy control participants, to compare working memory between participants with AD and controls, and to ...
Neuroscience (1)
Alzheimer Disease (2), Dementia (1), more mentions
Frontiers in aging neuroscience 
Increased life expectancy however, accompanied the emergence of age related chronic inflammatory states including the sporadic form of Alzheimer's disease (AD... periodontal microbiome, and highlight the challenges, the host faces, when dealing with unresolvable oral infections that may lead to clinical manifestations that are characteristic for AD Keyword: Alzheimer’s disease.
Neuroscience (3), Infectious Diseases (1)
Infections (5), Alzheimer Disease (3), Periodontitis (2), more mentions
Alzheimer's & dementia (New York, N. Y.) 
AbstractText: There is an urgent need to develop new treatments for Alzheimer's disease (AD) and to understand the drug development process for new AD therapies AbstractText: We assessed the agents in the AD pipeline as documented in clinicaltrials.gov for phase I, phase II, and phase III ... Keyword: Alzheimer's disease.
Neuroscience (7)
Alzheimer Disease (3), Dementia (3), Neurobehavioral Manifestations (1), more mentions
PLoS genetics 
Abstract: Alzheimer disease (AD), Frontotemporal lobar degeneration (FTD), Amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) have a certain degree of clinical, pathological and molecular overlap. Previous studies indicate that causative mutations in AD and FTD/ALS genes can be found in clinical familial AD. We examined the presence of causative and low frequency coding variants in the AD, FTD ...
Neurological and Central Nervous System Diseases (4)
Amyotrophic Lateral Sclerosis (4), Alzheimer Disease (2), Parkinson Disease (1), more mentions
NeuroImage. Clinical 
Abstract: Only a subset of mild cognitive impairment (MCI) patients progress to develop a form of dementia. A prominent feature of Alzheimer's disease (AD) is a progressive decline in language. We investigated if subtle anomalies in EEG activity of MCI patients during a word comprehension task could provide insight into the likelihood of conversion to AD.
Neuroscience (4)
Alzheimer Disease (2), Dementia (1), Mild Cognitive Impairment (1), more mentions
Stem cell reports 
Abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most studies have focused on neuronal cells, but astrocytes have also been suggested to contribute to AD pathology. We describe here the generation of functional astrocytes from induced pluripotent ...
Neuroscience (3), Stem Cell Research (1)
Alzheimer Disease (2), Brain Diseases (1), Neurodegenerative Diseases (1), more mentions
The Lancet. Neurology 
Targeting prodromal Alzheimer's disease: too late for prevention?.
Neuroscience (2)
Alzheimer Disease (2), more mentions
Brain : a journal of neurology 
Light at the beginning of the tunnel? Investigating early mechanistic changes in Alzheimer's disease..
Neuroscience (2)
Alzheimer Disease (2), more mentions
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