At the moment one can only conclude that in cases of MCA mirror aneurysms the larger one, with or without shape irregularities, is the unstable aneurysm and that this is the one that needs to be treated Keyword: ICA = internal carotid artery. Keyword: ICH = intracerebralhemorrhage. Keyword: MCA = middle cerebral artery.
... the independent impact that CAA has on cognition in the context of ageing and intracerebralhaemorrhage, as well as in Alzheimer's and other dementias. While the association between CAA and lobar intracerebralhaemorrhage (with its high recurrence risk) is now well recognised, a number of management dilemmas ... Keyword: cerebrovasculardisease.
Neuroscience (3), Cardiovascular Diseases (2), Neurological and Central Nervous System Diseases (1) Alzheimer Disease (2), Cerebral Amyloid Angiopathy (2), Vascular Dementia (1), more mentions
... 10 were clipped followed by revascularization, and 3 were coiled followed by staged cerebral revascularization. Of the 6 main trunk aneurysms in the posterior circulation, 4 underwent endovascular coiling and 2 were treated solely with revascularization. One patient died of contralateral intracerebralhemorrhage 6 months after the operation... Keyword: ICH = intracerebralhemorrhage. Keyword: IVH = intraventricular hemorrhage. Keyword: LSA = lenticulostriate artery.
... population, clinicians are more frequently encountering patients with atrial fibrillation who are also at risk of intracerebralhemorrhage due to cerebral amyloid angiopathy, the result of β-amyloid deposition in cerebral vessels... of cerebral amyloid angiopathy is particularly important when planning to start or restart anticoagulation after an intracerebralhemorrhage.
... the pharmacokinetic, anti-inflammatory, and safety profile of minocycline after intracerebralhemorrhage AbstractText: This study was a single-site, randomized controlled trial ... Adults ≥18 years with primary intracerebralhemorrhage who could have study drug administered within 24 hours of ... the dosing interval in 5 of 7 patients AbstractText: In intracerebralhemorrhage, a 400 mg dose of minocycline was safe and achieved ...
OBJECTIVE: To examine the associations of prediabetes, diabetes, and diabetes severity (as assessed by HbA1c and diabetes duration) with brain volumes and vascular pathology on brain MRI and to assess whether the associations of diabetes with brain volumes are mediated by brain vascular pathology.
RESEARCH DESIGN AND METHODS: Cross-sectional study of 1,713 participants in the Atherosclerosis Risk in Communities Neurocognitive Study (mean age 75 years, 60% female, 27% black, 30% prediabetes, and 35% diabetes) who underwent 3T brain MRI scans in 2011-2013. Participants were categorized by diabetes-HbA1c status as without diabetes (<5.7% [reference]), with prediabetes (5.7 to <6.5%), and with diabetes ([defined as prior diagnosis or HbA1c ≥6.5%] <7.0% vs. ≥7.0%), with further stratification by diabetes duration (<10 vs. ≥10 years).
RESULTS: In adjusted analyses, compared with participants without diabetes and HbA1c <5.7%, participants with prediabetes and those with diabetes and HbA1c <7.0% did not have significantly different brain volumes or vascular pathology (all P > 0.05), but those with diabetes and HbA1c ≥7.0% had smaller total brain volume (β -0.20 SDs, 95% CI -0.31, -0.09), smaller regional brain volumes (including frontal, temporal, occipital, and parietal lobes; deep gray matter; Alzheimer disease signature region; and hippocampus [all P < 0.05]), and increased burden of white matter hyperintensities (WMH) (P = 0.016). Among participants with diabetes, those with HbA1c ≥7.0% had smaller total and regional brain volumes and an increased burden of WMH (all P < 0.05) compared with those with HbA1c <7.0%. Similarly, participants with longer duration of diabetes (≥10 years) had smaller brain volumes and higher burden of lacunes (all P < 0.05) than those with a diabetes duration <10 years. We found no evidence for mediation by WMH in associations of diabetes with smaller brain volumes by structural equation models (all P > 0.05).
CONCLUSIONS: More-severe diabetes (defined by higher HbA1c and longer disease duration) but not prediabetes or less-severe diabetes was associated with smaller brain volumes and an increased burden of brain vascular pathology. No evidence was found that associations of diabetes with smaller brain volumes are mediated by brain vascular pathology, suggesting that other mechanisms may be responsible for these associations.
Endocrine Disorders (12), Cardiovascular Diseases (2) Diabetes Mellitus (12), Prediabetic State (4), Atherosclerosis (2), more mentions
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... of diabetes (3995 per 100 000 person-years in the screening group vs 4129 per 100 000 person-years in the non-screening group), intracerebralhaemorrhage (146 vs 140), renal failure (612 vs 649), cancer (3578 vs 3719), or 30 day mortality after cardiovascular surgery (44·57 vs 39·33 ...
AbstractText: Increasing data supports the role of bacterial inflammation in adverse events of cardiovascular and cerebrovasculardiseases. In our previous research, DNA of bacterial species found in coronary artery thrombus aspirates and ruptured cerebralaneurysms were mostly of endodontic and periodontal origin, where Streptococcus mitis group DNA was the most common ...
Thrombus (8), Deep Vein Thrombosis (3), Thrombosis (2), more mentions
... sporadic cerebral amyloid angiopathy (CAA) AbstractText: In a PubMed systematic literature search, we identified all case-control studies with extractable data relevant for the sensitivity and specificity of amyloid-PET positivity in symptomatic patients with CAA (cases) vs healthy participants or patients with spontaneous deep intracerebralhemorrhage (ICH) (control groups.
Cerebral Amyloid Angiopathy (2), Cerebral Hemorrhage (1), more mentions
Subclinical brain infarct was associated with increased vascular mortality among Hispanic participants only (HR: 2.9; 95% CI, 1.4-5.8) AbstractText: In this urban US sample, subclinical cerebrovascular lesions increased the risk of clinical stroke and vascular mortality and varied by race/ethnicity and lesion type Keyword: cerebrovasculardisease/stroke. Keyword: epidemiology.
Cardiovascular Diseases (16) Stroke (17), Leukoencephalopathies (1), more mentions
Seventy-three percent of patients were treated with venovenous and 27% with venoarterial ECMO. ECMO-associated intracerebralhemorrhage was diagnosed in 10.8% of patients... Six-month survival was 13% (Wilson confidence interval, 2%-47%) in patients with severe intracerebralhemorrhage compared to an overall survival rate of 57% (Wilson confidence interval, 45%-67.
Outcomes included the rate of any intracerebralhemorrhage, 90-day modified Rankin Score (mRS), the rate of good outcome (discharge mRS ≤2 ... odds of good outcome (odds ratio [OR], 0.811; 95% confidence interval [CI], 0.456-1.442), intracerebralhemorrhage (OR, 1.055; 95% CI, 0.595-1.871), parenchymal hematoma (OR, 0.353; 95% CI, 0.061-2.057 ...
AbstractText: Cerebral microbleeds are associated with an increased risk of intracerebralhemorrhage. Recent data suggest that microbleeds may also predict the risk of incident ischemic stroke. However, these results were observed in elderly individuals undertaking various medications and for whom causes of microbleeds and ischemic stroke may differ. We aimed to test the relationship between the presence of microbleeds and ...
... of 1 of 4 cardiovascular presentations (coronary heart disease [CHD], cerebrovasculardisease, heart failure, and peripheral vascular disease).During a mean follow ... ratio [HR]: 1.49; 95% confidence interval [CI]: 1.45 to 1.54), cerebrovasculardisease (HR: 1.07; 95% CI: 1.04 to 1.11), and heart failure ... Risk of CHD, cerebrovasculardisease, and heart failure in normal weight, overweight, and obese individuals ...
Anti-Obesity and Weight Loss (10), Cardiovascular Diseases (7), Endocrine Disorders (1) Cardiovascular Diseases (4), Heart Failure (4), Coronary Disease (2), more mentions
... treated otherwise according to the European Summary of Product Characteristics (EU SmPC) criteria for alteplase. Outcomes were 3-month functional independence (modified Rankin Scale score 0-2), mortality, and symptomatic intracerebralhemorrhage (SICH)/SITS. Results were compared between the groups treated in >3 to 4.5 and ≤3 hours AbstractText: Median age was 84 years; 61% were female in both groups.
Cardiovascular Diseases (6) Stroke (6), Cerebral Hemorrhage (1), more mentions